Dr Nick Eyre
Nick is a Research Fellow in Microscopy and Group Leader within the College of Medicine and Public Health at Flinders University. Since completing his Ph.D. in 2007, Nick’s research over the past 14 years has focussed on multiple aspects of virus-host interactions and viral genome replication for the related (+)RNA viruses hepatitis C virus (HCV), dengue virus (DENV) and Zika virus (ZIKV). In particular he has sought to apply sensitive and minimally invasive high-resolution imaging techniques and targeted and random manipulation of viral genomes to better understand the viral and host determinants of viral replication organelle formation, morphology and function and how these replication organelles interact with viral assembly platforms. This has led to his focus on the functions of the flavivirus NS1 protein; a critical determinant of viral RNA replication, infectious virus particle production and an important secreted pathogenic factor. He also has a strong interest in applying this understanding and associated techniques and molecular tools to the identification of novel antiviral therapeutics through high-throughput compound screening and mechanistic analysis of candidate antiviral drug activity.