BSc Hons, University of Adelaide PhD, University of Adelaide, Department of Biochemistry, Senior Lecturer
Phone: +618 82046658
Microbiology and Infectious Diseases, Flinders Medical Science and Technology, School of Medicine, Flinders University, Adelaide 5042, AUSTRALIA
My laboratory is interested in the host cell responses to viral infection that may be linked to regulating viral replication and disease pathogenesis. Our research is currently centered on dengue virus, a mosquito-borne virus of global and increasing significance, where the pathogenesis of severe dengue is associated with the host immune response and effects that increase the permeability of the vascular endothelium. The specific host cell proteins we believe are of interest in dengue virus infection include sphingosine kinase, an enzyme involved in maintaining sphingolipid homeostasis, cell signaling and the cell survival-death decision; and viperin, an interferon stimulated gene with key antimicrobial actions in the innate immune response. We utilize in vitro models of dengue virus infection reflecting a major cell target for infection in vivo (macrophages) and an important target for the pathogenic effects on the vasculature (endothelial cells) and molecular and cell biology approaches to investigate replication and changes in these cells in response to dengue virus infection.
BSc (Hons), PhD, University of Adelaide. Senior Lecturer, School of Biological Sciences, Flinders University
Tel: 08 8201 2765
In collaboration with Prof. P-J Wormald, development of a bacteriophage-based treatment for bacterial rhinosinusitis. This work, carried out by PhD student Amanda Drilling, shows excellent efficacy in an animal model and a human trial is underway.
Post-doctoral Research Associate Dr Tim Green, in my laboratory, is examining the immune responses of oysters and abalone to oyster and abalone herpesvirus infections. This work is funded by a grant from the Australian Seafood Cooperative Research Centre.